This paper presents the results of a retrospective analysis of congenital anomalies (CA) in the Republic of Moldova (RM) over a period of 11 years (2004-2014). The spread of CA in Moldova during the analyzed period is characterized by a stable level. In the infant mortality structure, congenital anomalies ranked second. There is a significant increase in CA, caused by chromosomal and cardiovascular system anomalies, with an average annual rate of 0.1 and 0.5%, respectively. At the same time,

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... CA of the musculoskeletal system has a reduction trend with a average annual rate of-2.7%. Stabilization of CA spread is the result of the implementation of the national program for the prevention and reduction of mortality and morbidity in children with congenital anomalies and hereditary diseases for the years 2013-2017. Some identified trends demonstrate the existence of gaps in the primary health care work concerning family planning.