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We present a novel large scale parallel computational model allowing 3-D simulations of cell colonies growing and interacting with variable environment. The cells are modelled as individual objects located in the lattice-free 3-D space. The model incorporates cellular environment described in a continuous manner. Discrete and continuous formulations are efficiently coupled in one model allowing considerations of cell colonies composed of up to 10 9 individual cells. This large scaledoi:10.1051/itmconf/20150500014 fatcat:tkc33cuhrrbzrndiu2r67vzuau