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Intracellular space is demarcated into functional membraneless organelles and nuclear bodies via the process of phase separation. Phase transitions are involved in many functions linked to such bodies as well as in gene expression regulation and other cellular processes. In this work we describe how the genome organizer SATB1 utilizes its prion-like domains to undergo phase transitions. We have identified two SATB1 isoforms with distinct biophysical behavior and showed how phosphorylation anddoi:10.1101/2021.08.11.455932 fatcat:mgfhd5eybbcdffrndrfq7zoqbm