Nanoemulsões como sistemas de liberação parenteral de fármacos

Fernanda Bruxel, Manoela Laux, Luisa Bartmann Wild, Michelle Fraga, Letícia S. Koester, Helder F. Teixeira
2012 Química Nova  
Recebido em 20/10/11; aceito em 29/3/12; publicado na web em 3/7/12 NANOEMULSIONS AS PARENTERAL DRUG DELIVERY SYSTEMS. Lipid nanoemulsions have recently been proposed as parenteral delivery systems for poorly-soluble drugs. These systems consist of nanoscale oil/water dispersions stabilized by an appropriate surfactant system in which the drug is incorporated into the oil core and/or adsorbed at the interface. This article reviews technological aspects of such nanosystems, including their
more » ... cluding their composition, preparation methods, and physicochemical properties. From this review, it was possible to identify five groups of nanoemulsions based on their composition. Biopharmaceutical aspects of formulations containing some commercially available drugs (diazepam, propofol, dexamethasone, etomidate, flurbiprofen and prostaglandin E1) were then discussed.
doi:10.1590/s0100-40422012000900023 fatcat:tjh4hvhl3je63mqom7qpdykv2u