Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

Haosha Tang, Yunyan Kuang, Julan Zeng, Xiaofang Li, Wei Zhou, Yuan Lu
2019 RSC Advances  
(E)-β-Trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates under metal-free conditions. p-Acetylphenyl in R1 has the best activities against several tumor cells.
doi:10.1039/c9ra06368d fatcat:hz6ooifbh5ebroypktcn765o7u