Modulation of dynamin function by small molecules

Susanne Eschenburg, Thomas F. Reubold
2018 Biological chemistry  
Dynamins are essential as membrane remodelers in various cellular processes, like receptor-mediated endocytosis, synaptic vesicle recycling and spermatogenesis. Moreover, dynamin is involved in the internalization of numerous viruses and in the motility of several cancer cell lines. As tools for dissecting the underlying mechanisms of these important biological processes and as potential future therapeutics, small molecules have been developed in the last two decades that modulate the functions
more » ... of dynamin. In this review we give an overview of the compound classes that are currently in use and describe how they affect dynamin function.
doi:10.1515/hsz-2018-0257 pmid:30067507 fatcat:z2f5fxfaerfzvmq7ax4vnickhu