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This study explored the expression of high mobility group box 1 protein (HMGB1) expression in patients with sepsis and its effects on immune function and prognosis. Patients with sepsis (n = 112) were divided into the mild group (MG, n = 59) and severe group (SG, n = 53) according to the disease severity of sepsis. Fifty healthy people who came to our hospital for physical examination at the same time served as the control group (CG). Serum HMGB1, CD4+, and CD8+ expression levels and CD4+/CD8+doi:10.1080/26895293.2020.1734671 fatcat:jvvbibgm25hwbfvjdmrrvf5myi