Platypnea orthodeoxia syndrome in a patient with pulmonary arterial hypertension

T. Sinanis, U. Krüger, W.H. Schöls
2017 Clinical Case Reports and Reviews  
Platypnea orthodeoxia syndrome (POS) is a rare syndrome traditionally defined as dyspnea or hypoxemia observed when changing from a recumbent to an upright or seated position. A patent foramen ovale (PFO) is oft part of the underlying pathophysiology. Here, a 70-year-old woman with known PFO presents with new symptoms of a platypnea orthodeoxia syndrome. A pulmonary arterial hypertension (PAH), treated with Ambrisentan for years, was also known. In order to clarify the etiology of the new
more » ... gy of the new hemodynamic state we performed a transesophageal echocardiography (TEE) in an upright position, which excluded a PFO related cause of symptoms. A further investigation shown a COPD (Chronic Obstructive Pulmonary Disease), the treatment of which relieved of symptoms. This is the first described case of Platypnea orthodeoxia syndrome in patient with PAH. Although PFO is a common cause of POS and a PFO closure is often advised, careful differential diagnosis should be kept in mind.
doi:10.15761/ccrr.1000374 fatcat:nyer34qi6bfahb7bu2pr4eiori