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Cyclic AMP Raises Intracellular Ca 2+ in Human Megakaryocytes Independent of Protein Kinase A
2002
Arteriosclerosis, Thrombosis and Vascular Biology
The immature megakaryoblastic cell line MEG-01 responds to iloprost with an increase in cytosolic Ca 2ϩ and cAMP. The Ca 2ϩ response is almost absent in CHRF-288-11 cells, but cAMP formation is preserved in this more mature megakaryoblastic cell line. Also, in human hematopoietic stem cells, iloprost induces a Ca 2ϩ response and cAMP formation. The Ca 2ϩ response is downregulated during megakaryocytopoiesis, but cAMP formation remains unchanged. The Ca 2ϩ increase may be caused by cAMP-mediated
doi:10.1161/hq0102.101515
pmid:11788480
fatcat:krpgeozcoff2nmdmah55x7ll54