Pathological Society of Great Britain and Ireland. 180th Meeting, 18-21 January 2000

2000 Journal of Pathology  
show an incidence of colorectal cancer some fourfold in excess of Western populations, despite their lower incidence among older age groups. We have already shown that in Western patients 35 years of age or younger 58% have the RER+ phenotype and 42% have germ-line mutations in Msh2, whilst in turnours from young Hong Kong Chinese, the proportion of RER+ tuinours is very similar (62%), 55% of the RER+ tumours having gemline mutations in Msh2 Comparative genomic hybridisation (CGH) was applied
more » ... DNA from the RER-tumours from these populations, permitting classification of this subset of tumours into those with few sites of chromosome imbalance and those with many. Of 12 RER-(uniours from young Chinese, 50% showed little chromosome imbalance by CGH, whilst this proportion was 80% in 11 Scottish young patients. When the CGH-detected abnormalities were compared between cancers arising in young and old patients, significantly fewer changes were observed in chromosome 7p, 7q, 8p, 8q, 13q and 2Oq (all commonly affected by reduplication or deletion in late onset of RERcancers) in the Chinese and Western populations taken together. The data thus show that colorectal cancers arising in young people, both amongst Hong Kong Chinese and in Scotland, differ in their molecular profile from colorectal cancers in older patients in these locations, being enriched in both RER+ and RER-chromosomally stable types. However, the factors responsible for the higher incidence of colorectal cancers in young Chinese relative to young Scots are still obscure.
doi:10.1002/path.1711900102 fatcat:ixrzp5vhunbxnguvoasez3c2ii