Imipenem plus fosfomycin as salvage therapy for vertebral osteomyelitis

Itaru Nakamura, Tetsuo Yamaguchi, Kotaro Aoki, Yuri Miura, Satoko Sato, Hiroaki Fujita, Hidehiro Watanabe
2020 Antimicrobial Agents and Chemotherapy  
We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-non-susceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 (mprF), and SA1531 (ald). Four weeks of combination treatment using imipenem/cilastatin (1.5 g per
more » ... astatin (1.5 g per day) and fosfomycin (4.0 g per day) resulted in clinical improvement.
doi:10.1128/aac.01746-20 pmid:32958715 fatcat:x5hbhknjkffg7pc2ybcxvybbla