Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases

Federico Alonso Zumaya-Estrada, María Carmen Rodríguez, Mario Henry Rodríguez
2017 Salud Pública de México  
Zumaya-Estrada FA, Rodríguez MC, Rodríguez MH. Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases. Salud Publica Mex 2018;60:77-85. Abstract Objective. To analyze the current knowledge of pathogeninsect interactions amenable for the design of molecularbased control strategies of vector-borne diseases. Materials and methods. We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in
more » ... ticipate in interactions during their vectors infection. Results. Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Conclusion. Disruption of processes by blocking vector-pathogen interactions provides several candidates for molecular control strategies, but TBV and GMI efficacies are still limited and other secondary effects of GMI (improving transmission of other pathogens, affectation of other organisms) should be discarded. Zumaya-Estrada FA, Rodríguez MC, Rodríguez MH. Moléculas candidatas para el control de enfermedades transmitidas por vector mediante el bloqueo de interacciones patógeno-insecto. Salud Publica Mex 2018;60:77-85.
doi:10.21149/8140 pmid:29689660 fatcat:wcotlmx5qzhxxl67ronl56vxta