The prominent role of the S100A8/S100A9-CD147 axis in the progression of penile cancer [article]

Tobias Mohr, Anabel Zwick, Muriel Charlotte Hans, Isabelle Ariane Bley, Felix Leon Braun, Oybek Khalmurzaev, Vsevolod Borisovich Matveev, Philine Loertzer, Alexey Pryalukhin, Arndt Hartmann, Carol-Immanuel Geppert, Hagen Loertzer (+7 others)
Currently, no established biomarkers are recommended for the routine diagnosis of penile carcinoma (PeCa). The rising incidence of this human papillomavirus (HPV)-related cancer entity highlights the need for promising candidates. The Calprotectin subunits S100A8 and S100A9 mark myeloidderived suppressor cells in other HPV-related entities while their receptor CD147 was discussed to identify patients with PeCa at a higher risk for poor prognoses and treatment failure. We thus examined their
more » ... ession using immunohistochemistry staining of PeCa specimens from 74 patients on tissue microarrays of the tumor center, the invasion front, and lymph node metastases. Notably, whereas the tumor center was significantly more intensively stained than the invasion front, lymph node metastases were thoroughly positive for both S100 subunits. An HPV-positive status combined with an S100A8 + S100A9 + profile was related with an elevated risk for metastases. We observed several PeCa specimens with S100A8 + S100A9 +infiltrating immune cells overlapping with CD15 marking neutrophils. The S100A8 + S100A9 + CD15 + profile was associated with dedifferentiated and metastasizing PeCa, predominantly of HPV-associated subtype. These data suggest a contribution of neutrophil-derived suppressor cells to the progression of HPV-driven penile carcinogenesis. CD147 was elevated, expressed in PeCa specimens, prominently at the tumor center and in HPVpositive PeCa cell lines. CD147 + HPV + PeCa specimens were with the higher-Frontiers in Oncology 01
doi:10.22028/d291-37621 fatcat:ncnlycdvpnhyjh4w5kycuf6z2m