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On the Fate of Extracellular Hemoglobin and Heme in Brain
Journal of Cerebral Blood Flow and Metabolism
Intracerebral hemorrhage (ICH) is a major cause of disability in adults worldwide. The pathophysiology of this syndrome is complex, involving both inflammatory and redox components triggered by the extravasation of blood into the cerebral parenchyma. Hemoglobin, heme, and iron released therein seem be important in the brain damage observed in ICH. However, there is a lack of information concerning hemoglobin traffic and metabolism in brain cells. Here, we investigated the fate of hemoglobin anddoi:10.1038/jcbfm.2009.34 pmid:19337276 fatcat:pcbjqzxftrg2vllhf2dyoatz2m