Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

I.A. Gutiérrez-Hurtado, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, L.E. Figuera, G.M. Zúñiga-González, K. Gomez-Mariscal, C.A. Ronquillo-Carreón, M.P. Gallegos-Arreola
2016 Genetics and Molecular Research  
The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 15 (2): gmr.15028199 polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms
more » ... >A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295-8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α -308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.
doi:10.4238/gmr.15028199 pmid:27421001 fatcat:ksu575rj3fdwtbknxvxn4ai6ya