Effect of sodium selenite on bone repair in tibiae of irradiated rats

Anna Silvia Setti da Rocha, Flávia Maria de Moraes Ramos-Perez, Frab Norberto Bóscolo, Flavio Ricardo Manzi, Mariliani Cchicarelo, Solange Maria Almeida
2009 Brazilian Dental Journal  
This study evaluated the radioprotective effect of sodium selenite on the bone repair process in tibiae of female rats. For such purpose, 100 female Wistar rats (Rattus norvegicus, albinus) were randomly assigned to 4 groups (n=25), according to the treatment received: administration of distilled water (control); administration of sodium selenite; gamma radiation; and administration of sodium selenite plus gamma radiation. A bone defect was prepared on both tibiae of all animals. Three days
more » ... als. Three days after surgery, the gamma radiation and selenium/gamma radiation groups received 8 Gy gamma rays on the lower limbs. Five animals per group were sacrificed 7, 14, 21, 28 days after surgery for evaluation of the repair process by bone volumetric density analysis. The 5 animals remaining in each group were sacrificed 45 days postoperatively for examination of the mature bone by scanning electron microscopy. Based on all analyzed parameters, the results of the present study suggest that sodium selenite exerted a radioprotective effect in the bone repair of tibia of irradiated rats.
doi:10.1590/s0103-64402009000300002 pmid:19784461 fatcat:yahkan3irvfrhnlzztfs462fzu