Axonal integrity predicts cortical reorganisation following cervical injury

Patrick Freund, Claudia A Wheeler-Kingshott, Zoltan Nagy, Nikos Gorgoraptis, Nikolaus Weiskopf, Karl Friston, Alan J Thompson, Chloe Hutton
2012 Journal of Neurology, Neurosurgery and Psychiatry  
Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal corddthe presumed basis of ensuing clinical impairment. Objective The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish how microstructural white matter changes in the CST are related to cross-sectional spinal cord area and cortical
more » ... organisation of the sensorimotor system in subjects with traumatic SCI. Methods Nine volunteers with cervical injuries resulting in bilateral motor impairment and 14 control subjects were studied. The authors used diffusion tensor imaging to assess white matter integrity in the CST, T1-weighted imaging to measure cross-sectional spinal cord area and functional MRI to compare motor task-related brain activations. The relationships among microstructural, macrostructural and functional measures were assessed using regression analyses. Results Diffusion tensor imaging revealed significant differences in the CST of SCI subjectsdcompared with controlsdin the pyramids, the internal capsule, the cerebral peduncle and the hand area. The microstructural white matter changes observed in the left pyramid predicted increased task-related responses in the left M1 leg area, while changes in the cerebral peduncle were predicted by reduced cord area. Conclusion The observed microstructural changes suggest trauma-related axonal degeneration and demyelination, which are related to cortical motor reorganisation and macrostructure. The extent of these changes may reflect the plasticity of motor pathways associated with cortical reorganisation. This clinically viable multimodal imaging approach is therefore appropriate for monitoring degeneration of central pathways and the evaluation of treatments targeting axonal repair in SCI.
doi:10.1136/jnnp-2011-301875 pmid:22492214 pmcid:PMC3348614 fatcat:jqy5uc3m6batrkjuljiwg7evzy