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was any connection between the enlarged hypo¬ physis and the enlargement of the nerves. Klebs was inclined to attribute the disease to the prolif¬ eration of blood-vessels, but this was purely fan¬ ciful and speculative, and at present the true pathology remains shrouded in profound mystery. As regards the matter of prognosis, this was not particularly bad so far as life was concerned. Indoi:10.1001/jama.1888.04360040033009 fatcat:hc5zaot25jfhniqrti4hf7skve