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readily established, however, that malaria is the prevalent modifying influence in the class of cases cited. This can be done by the timely and judi¬ cious employment of our most reliable antimalarial agent, quinine. These facts are worthy of careful study and investigation. The study of climatology should engage the most earnest efforts of our schools and colleges throughout the country. A clearer un¬ derstanding of the influences of climate in the production and modification of diseases woulddoi:10.1001/jama.1889.02400960020006 fatcat:ixlypmulwrabte227aui4drsmi