EFFECTS OF SIX ANTI-INFLAMMATORY CHINESE HERBS ON LPS/IFN-γ-INDUCED NITRIC OXIDE PRODUCTION IN RAW264.7 MACROPHAGES

Wen-Fei Chiou, Cheng-Jen Chou, Han-Chieh Ko, Chieh-Fu Chen
2000 J Chin Med   unpublished
The present study was designed to evaluate whether the six Chinese herbs (Davallia divaricata, Dd; Nothapodytes foetida, Nf; Orobanche caerulescens, Oc; Spiranthes sinensis, Ss; Taxillus liquidambaricolus, Tl; Viscum alniformosanae, Va) commonly used as anti-inflammatory drugs in traditional Chinese medicine, influence the induction of nitric oxide (NO), a mediator involved in inflammation. RAW264.7 cell was used as target cell and activated by lipopolysaccharide (LPS) plus interferon-γ
more » ... Our results indicated that two out of six ethanolic crude extracts of Chinese herbs (Nf and Tl) significantly suppressed LPS/IFN-γ-induced NO production in a dose-dependent manner. It is unlikely that cytotoxicity was involved, because no cell deaths were observed. The result was correlated with their putative pharmacological activities. The remaining ethanloic extracts of the other Chinese herbs only had little or no effect on NO production.
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