Glutathione activation of an organometallic half-sandwich anticancer drug candidate by ligand attack

Xin Zhang, Fortuna Ponte, Elisa Borfecchia, Andrea Martini, Carlos Sanchez-Cano, Emilia Sicilia, Peter J. Sadler
2019 Chemical Communications  
Density functional theory calculations and X-ray absorption spectroscopic data suggest an unusual activation mechanism for this potent Os anticancer complex: catalytic attack by intracellular thiol glutathione on the azo bond of the chelated ligand.
doi:10.1039/c9cc06725f pmid:31742266 fatcat:6qg5bki5vnbg5bpjrqsxo5y25a