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Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS). Although the paralogous phosphorylation site S714 in PER1 is conserved in mice, its specific function in circadian organization remains unknown. Here, we find that the PER1 S714G mutation accelerates the molecular feedback loop. Furthermore, hPER1 S714G mice, but not hPER2 S662G mice, exhibit peak time of fooddoi:10.1016/j.celrep.2014.04.032 pmid:24857656 fatcat:iq65v52ykbgefgom2o6yrvkrwe