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In the XVI century the Portuguese have contributed to the introduction of tobacco in the world. The tobacco plant came from America and its therapeutic properties were attributed to the leaves by a Spanish physician. The pathogenic effects of tobacco were shown only in the middle of the XX century. Since then many reports have demonstrated the harmful role of tobacco in several diseases, particularly in cardiovascular and pulmonary areas. The still existing relatively good social acceptabilitydoi:10.1016/s0873-2159(15)30760-1 fatcat:rsiyabdfenbcvd4ttxmobmw55i