A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Biphasic Regulation of Leukocyte Superoxide Generation by Nitric Oxide and Peroxynitrite
2000
Journal of Biological Chemistry
Preserved Fulltext
Activation of the NADPH oxidase-derived oxidant burst of polymorphonuclear leukocytes (PMNs) is of critical importance in inflammatory disease. PMN-derived superoxide (O 2 . ) can be scavenged by nitric oxide (NO ⅐ ) with the formation of peroxynitrite (ONOO ؊ ); however, questions remain regarding the effects and mechanisms by which NO ⅐ and ONOO ؊ modulate the PMN oxidative burst. Therefore, we directly measured the dose-dependent effects of NO ⅐ and ONOO ؊ on O 2 . gener-
doi:10.1074/jbc.m006341200
pmid:10976106
fatcat:f7ra5jqqgjbdbpoclul3j2vyr4