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Motor neurons project axons from the hindbrain and spinal cord to muscle, where they induce myofibre contractions through neurotransmitter release at neuromuscular junctions. Studies of neuromuscular junction formation and homeostasis have been largely confined to in vivo models. In this study we have merged three powerful tools - pluripotent stem cells, optogenetics and microfabrication - and designed an open microdevice in which motor axons grow from a neural compartment containing embryonicdoi:10.1002/adbi.201800307 pmid:31428672 pmcid:PMC6699992 fatcat:xesgqsxnf5am5ddg2shvxrexe4