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We show that image registration using conventional interpolation and summation approximations of continuous integrals can generally fail because of resampling artifacts. These artifacts negatively affect the accuracy of registration by producing local optima, altering the gradient, shifting the global optimum, and making rigid registration asymmetric. In this paper, after an extensive literature review, we demonstrate the causes of the artifacts by comparing inclusion and avoidance ofdoi:10.1109/tip.2012.2224356 pmid:23076044 pmcid:PMC3694571 fatcat:vzu6liuozjclno7ao4f3wsk2n4