The role of anti-TNF therapy in ulcerative colitis
Mjesto anti-TNF terapije u lijecenju ulceroznog kolitisa

Silvija Cuković-Cavka, Boris Vucelić, Marija Crncević Urek, Marko Brinar, Niksa Turk
2013 Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti  
Anti-TNF-alfa molecules are currently being used to treat ulcerative colitis regarding to the fact that TNF-alpha has an important role in the pathogenesis of IBD. Although these drugs improved the therapy of patients, immunogenicity limits their potential for clinical use. Infliximab and adalimumab are effective for induction and maintenance of remission in outpatients with moderate to severe steroid-refractory ulcerative colitis. Biologics can be a drug of choice for patients with refractory
more » ... ts with refractory proctitis and refractory pouchitis. In hospitalized patients with steroid-resistant severe ulcerative colitis who are candidates for colectomy, infliximab may be second-line option. Adequate long-term maintenance therapy with anti-TNF is required after rescue therapy for a sustained benefit. Regarding to the known risk for side-effects of anti-TNF drugs especially in patients concomitantly treated with thiopurines it is urgent future research.
pmid:24471300 fatcat:ttw6z6geubaz5gibfnyzvlvxge