Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocytes injury via lncRNA AK003290/miR-124-5p signaling [post]

2019 unpublished
Objective Acute myocardial infarction (AMI) is the leading cause of death and one of the heaviest healthy burden globally nowadays. Tanshinone IIA (TSA) is the major active compound extracted form Salvia miltiorrhiza Bunge possessing various of pharmacology activities. The present study aimed at investigating the role of TSA in AMI and underlying mechsniam. Methods Quantitative real-time PCR (qRT-PCR) and western blot assay were performed to detect the expression of genes and proteins. Cell
more » ... proteins. Cell apoptosis was detected by Annexin/V PI staining and flow cytometry. The amount of LDH, MDA and ROS were detected using commercial kits. FISH experiment was used to detect the expression
doi:10.21203/rs.2.18747/v1 fatcat:as6x3sxk4bagpneu4qbh3efc3u