Tandem Application of Sodium Lauryl Sulfate and n-Propanol Does Not Lead to Enhancement of Cumulative Skin Irritation

Ulrike P. Kappes, Nina Göritz, Wal
2001 Acta Dermato-Venereologica  
skin disease. The study was approved by the local ethics committee Irritant contact dermatitis has a broad spectrum of clinical and informed consent was obtained from all participants. Subjects features and is a leading cause of occupational disease worldwide. were instructed not to apply detergents, moisturizers or emollients It has been shown previously that a combination of chemically directly on the test area during the investigation period of 5 days. diOE erent irritants may cause an
more » ... may cause an additive eOE ect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investi-Procedure gated in 20 human volunteers using non-invasive bioengineering Four adjacent skin areas of clinically normal skin were premarked as methods, such as measurement of transepidermal water loss and test ® elds on a medial volar forearm of each subject. Placement of chromametry. N-propanol did not enhance cumulative skin irritatest ® elds was otherwise random. Irritants were applied for 30 min
doi:10.1080/000155501317208327 pmid:11859941 fatcat:rbsiyyf36fhptmgsxkkmq6iuse