In vivobiodistribution and toxicity depends on nanomaterial composition, size, surface functionalisation and route of exposure

S. Harper, C. Usenko, J.E. Hutchison, B.L.S. Maddux, R.L. Tanguay
2008 Journal of Experimental Nanoscience  
Rapid, relevant and efficient testing strategies are necessary to evaluate nanoparticle-biological interactions of emerging nanoparticles/nanomaterials due to the anticipated, unprecedented growth of the nanotechnology industry. Here we present an approach that utilizes a dynamic whole animal (embryonic zebrafish) assay to identify in vivo responses to nanomaterial exposure and to define physicochemical properties that result in adverse biological consequences. Our results demonstrate the
more » ... monstrate the utility of this model as an effective and accurate tool to assess the biological activity and toxic potential of nanomaterials in a short period of time with minimal cost.
doi:10.1080/17458080802378953 fatcat:qditnwlurfhdjb4cxkbwd6yzfa