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Biopolymers and Cell
Сoenzyme A-synthases α and β (CoASy α and CoASy β) contain proline rich regions which may bring them into complexes with SH3-domain containing proteins. To test whether CoASy isoforms can bind to SH3 domains we performed in vitro pull down experiments. It was found that CoASy β N-terminal extension, which is especially abundant in prоlines, can interact specifically and directly with SH3 domains of tyrosine kinases Fyn and CSK, phospholipase Cγ, NADPH oxidase activator 1 -p67phox, anddoi:10.7124/bc.000799 fatcat:top7abnzzzhljibjhqofup4b6a