Stages of development of bladder of rats in the early postnatal period

A.Y. Khitrik, V.M. Yevtushenko, V.S. Bushman, A.G. Necheporenko, M.V. Aksamityeva
2019 Reports of Vinnytsia National Medical University  
The actual problem of practical medicine is the treatment of diseases of the lower department of the urinary system and about 20% of this pathology accounts for the proportion of the bladder. A histological survey of the bladders of 64 rats was conducted. Quantitative analysis of the results of the morphometric study was carried out using methods of variation statistics using Excel and STATISTICA programs. The aim of the study was to determine the average thickness of their own plate, muscle
more » ... wn plate, muscle membrane, the average number of blood vessels in the microcirculation bed per unit area, their diameter, the number of lymphocytic cells. It was found that during the early stage of postnatal ontogenesis (up to 90 days of life of rats), the following changes in the structure of the bladder are observed: an increase in the thickness of the tear and muscle of the wall of the bladder occurs; an increase in the mucous membrane of bladder cells of the immunomorphological complex (lymphocytes, macrophages, and lymphocytic cell clusters), changes in the quantitative aspect and in the diversity of the cellular composition; there is an increase in the number of blood vessels in the microcirculation bed. These changes occurred progressively, with maximum expressiveness in the period of 30 days of life and subsequent stabilization of indicators. Such indications may be associated with a change in the type of nutrition of the rat, since 14 to 21 days they have a transition from dairy to natural nutrition. In the future, it is planned to conduct an investigation of the effect of antigenic stimulation on the structure of the wall of the bladder.
doi:10.31393/reports-vnmedical-2019-23(1)-13 fatcat:c5ehsv3jrrfrxedv2et3g23fim