Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist)

Rita de Cássia Saraiva Nunomura, Angelo C. Pinto, Sergio Massayoshi Nunomura, Adrian Martin Pohlit, Ana Cláudia Fernandes Amaral
2012 Química Nova  
FIOCRUZ/Farmanguinhos), Rua Sizenando Nabuco, 100, 21041-250 Rio de Janeiro -RJ, Brasil Recebido em 26/5/12; aceito em 27/9/12; publicado na web em 26/10/12 CHEMICAL CONSTITUENTS FROM STEMS OF Simaba guianensis subesp. ecaudata (Cronquist). Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the
more » ... inol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound.
doi:10.1590/s0100-40422012001100009 fatcat:mtnumcso2zbk3futx47akn5lxm