Inflammatory Microenvironment in Prostate Carcinogenesis [chapter]

Geraldine Gueron, Javier Cotignola, Elba Vazquez
2013 Advances in Prostate Cancer  
idative damage to macromolecules in epithelial cells and can react with other cellular components initiating a free radical chain reaction, thus sustaining the prostate carcinogenic process and its progression. The molecular mechanisms that prime the pathogenesis of cancer-related inflammation are complex and involve a delicate interplay between tumor and its microenvironment. In prostate tumors, the switch to an angiogenic phenotype is known to be critical for its progression. Unless a tumor
more » ... n. Unless a tumor can stimulate the formation of new blood vessels, it remains restricted to a microscopic size. Inflammation and hypoxia are widely accepted as key elements in the induction of angiogenesis. Dissection of the diversity of cancer-related inflammation is critical for the design of innovative diagnostic and therapeutic strategies in prostate cancer. Specifically, the following topics and molecular events are reviewed and discussed in this chapter: • The cytokine and chemokine orchestration and the associated downstream genetic events that cause neoplastic transformation in the prostatic tissue.
doi:10.5772/52636 fatcat:ufs3diltf5frphn72oeufgkxda