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FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes
2001
Journal of Cell Science
Hrs, an essential tyrosine kinase substrate, has been implicated in intracellular trafficking and signal transduction pathways. The protein contains several distinctive domains, including an N-terminal VHS domain, a phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding FYVE domain and two coiled-coil domains. Here we have investigated the roles of these domains in the subcellular localisation of Hrs. Hrs was found to colocalise extensively with EEA1, an established marker of early endosomes.
pmid:11493665
fatcat:hagcnmoscjbwzbmbc3evkbn4ou