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Brain imaging evidence of preclinical Alzheimer's disease in normal aging
2006
Annals of Neurology
Objective: This study was designed to test the hypothesis that baseline glucose metabolism and medial temporal lobe brain volumes are predictive of cognitive decline in normal older people. Methods: We performed positron emission tomography using [ 18 F]fluorodeoxyglucose and structural magnetic resonance imaging at baseline in 60 cognitively normal community-dwelling older subjects who were part of a longitudinal cohort study. Subjects were followed for a mean of 3.8 years, with approximately
doi:10.1002/ana.20799
pmid:16470518
fatcat:dhzhjehga5dvjeozg753kut3sq