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The most replicated blood biomarker for monitoring Alzheimer's disease is neurofilament light (NFL). Recent evidence revealed that the plasma level of the NFL has a strong predictive value in cognitive decline and is elevated in AD patients. The Diffusion Tensor Imaging (DTI) is understood to reflect white matter disruption, neurodegeneration, and synaptic damage in AD. However, few investigations have been carried out on the association between plasma NFL and white matter microstructuredoi:10.21203/rs.3.rs-115308/v2 fatcat:7rcdsprvfffzrlaplpetra5pjm