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A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens
[article]
2020
bioRxiv
pre-print
Inflammation and ageing-related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline and neurodegenerative disease. However, it is unclear how these blood-based patterns relate to patterns within the brain, and how each associates with central cellular profiles. In this study, we profiled DNA methylation in both the blood and in five post-mortem brain regions (BA17, BA20/21, BA24, BA46 and hippocampus) in 14 individuals from the Lothian
doi:10.1101/2020.11.30.404228
fatcat:apwka4537fh2jkxs4oie47fnwq