1,10-Secoguaianolides from Artemisia austro-yunnanensis and Their Anti-Inflammatory Effects

Lan Liu, Weifeng Dai, Cheng Xiang, Jun Chi, Mi Zhang
2018 Molecules  
Seven 1,10-secoguaianolides 1-7, including a new one (compound 1), were isolated from Artemisia austro-yunnanensis and identified by HRESIMS and other spectroscopic methods. Their anti-inflammatory effects were evaluated by the model of LPS-induced RAW264.7 cells in vitro. Bioassay results showed that six of them (1-4, 6 and 7), with the exception of 5, produce some cytotoxicity on RAW264.7 cells at its high dosage, can significantly decrease the release of NO, TNF-α, IL-1β, IL-6 and PGE2 in a
more » ... IL-6 and PGE2 in a dose dependent manner, and down-regulate the expression of proteins iNOS and COX-2. The mechanism study indicated they regulated the NF-κB dependent transcriptional activity through decreasing the phosphorylation of NF-κB. Further, the relationship between their structures and cytokines to anti-inflammatory were studied by PCA and discussed.
doi:10.3390/molecules23071639 pmid:29976846 fatcat:pwifitf6sfh3nfvrr6aw3txqji