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Periodontal vaccine is a boon in periodontics. The demanding primary role of any periodontal vaccine would be to eradicate the global periodontal disease burden with the ultimate purpose of lowering periodontal disease associated morbidity in humans. In late eighteenth century, Edward Jenner developed and established the principle of vaccination using the cross protection conferred by cowpox virus, which is non pathogenic in humans. Vaccination accomplished can be active immunization, passivedoi:10.13005/bpj/704 fatcat:4sdfit7ourhy7ahdem3l2hxwwu