Diabetic neuropathy is the most frequent chronic complication of Diabetes Mellitus (DM), currently considered an irreversible end-organ damage complication. The present case concerns a teenage patient, who after effective glycemic control, was shown to regain sensitive and autonomic nerve function. Case Report: An 18-year-old female patient with Type 1 DM with 6 years of evolution since diagnosis and poor metabolic control (HbA1c 13%) presents to our outpatient clinic with severe sock-pattern

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... rning pain sensation in both lower limbs, which is perceived to have worsened in the previous 6 months despite receiving gabapentin and pregabalin, prescribed in another health center. At physical examination, orthostatic hypotension was evidenced after a fast transition to standing position, tachycardia, muscular hypotrophy of both quadriceps and sural triceps, with a negative Rydel-Seiffert test and a positive Romberg test. Patellar and calcaneal osteotendinous hyporreflexia were found, while hyperalgesia and allodynia to palpation of both feet were present. The RINES-VALCARDI test yielded 8 points at first consultation. She was given patient education concerning her disease and started a strict diet as well as an appropriate insulin therapy to achieve metabolic control. She was treated with duloxetine and capsaicin cream, treatments which she abandoned 6 months later with no observable or measurable relapse of her nerve dysfunctional symptoms; not even one year afterwards. Discussion: This case is unique due to several aspects: The severity of hyperalgesia, and the reversibility of both peripheral and autonomic symptoms after glycemic control and patient education. These elements are fundamental pertaining to reversion of nerve damage.