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Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
[article]
2021
bioRxiv
pre-print
Selective autophagy of damaged mitochondria, intracellular pathogens, protein aggregates, endoplasmic reticulum, and other large cargoes is essential for health. The presence of cargo initiates phagophore biogenesis, which entails the conjugation of ATG8/LC3 family proteins to membrane phosphatidylethanolamine. Current models suggest that the presence of clustered ubiquitin chains on a cargo triggers a cascade of interactions from autophagic cargo receptors through the autophagy core complexes
doi:10.1101/2021.01.08.425958
fatcat:fcweqgrcajf6fh4gnke2tqxi5u