Increased levels of serum Hcy and UA as well as the thickness of carotid intima-media correlates with the severity of coronary artery lesions [post]

2019 unpublished
To investigate the correlation between serum homocysteine (Hcy) and uric acid (UA) levels as well as the carotid intima-media thickness (IMT) and the severity of coronary artery lesions in elderly patients with coronary heart disease (CHD). Methods: A total of 156 elderly patients (≥60 years old) with CHD in the study group ; 54 patients with normal coronary artery were selected as the control group. The study group were further divided into low (≤20 points, n=72), middle (21-39 points, n=56)
more » ... -39 points, n=56) and high (≥40 points, n=28) score groups according to SYNTAX score. Serum Hcy and UA levels, IMT, Gensini and Sullivan scores were measured and analyzed by Pearson correlation. The risk factors for CHD and the correlation were analyzed by single factor analysis and logistic regression. Results: SYNTAX scores showed that the levels of serum Hcy, UA, and the IMT in middle [(20.03 ± 7.88) μmol/L, (326.34 ± 79.34) μmol/L, (1.26 ± 0.07) mm)] and high score [(28.98 ± 8.04) μmol/L, (456.67 ± 98.34) μmol/L, (1.33 ± 0.08) mm] groups were significantly higher compared to the low score group [(11.34 ± 6.83) μmol/L, (206.78 ± 77.45) μmol/L, (1.19 ± 0.05) mm)], while the high score group had the highest levels (all P < 0.001). Serum Hcy, UA levels and the IMT were positively correlated with SYNTAX and Sullivan scores (all P < 0.001). Additionally, male gender, smoking, history of hypertension, systolic pressure, pulse pressure, Hcy, UA, IMT, and BMI independently correlated with the severity of CHD (all P < 0.05). Conclusions: The serum levels of Hcy and UA and the IMT in patients with CHD were significantly elevates, and positively correlated with the severity of coronary artery lesions, which may serve as diagnostic indicators. Background Coronary heart disease (CHD) is a common disease of the human circulatory system. It is caused by many factors including the person's lifestyle, dietary habits, heredity, and so on. Coronary atherosclerotic heart disease, the most common type of CHD, is caused by coronary atherosclerotic stenosis, which leads to necrosis of the myocardium due to the insufficient blood supply. In addition, broadly speaking, the stenosis of the lumen caused by extensive inflammation and embolism also lead to CHD [1] . For a long time, the "gold standard" for evaluating the severity of coronary artery lesions has been the coronary angiography, but it is too traumatic to be suitable for elderly patients.
doi:10.21203/rs.2.13693/v2 fatcat:tgqe4q3gwnaqbhlm54xd7mm3o4