Biological monitoring of exposure to nerve agents

J Bajgar
1992 Occupational and Environmental Medicine  
Changes in acetylcholinesterase activity in blood and some organs of rats after intoxication with sarin, soman, VX, and 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate (GV), in doses of roughly 2 x LD5. given intramuscularly, were obtained from published data and by experiment. The time course of inhibition of acetylcholinesterase in blood, regions ofbrain, and diaphragm and the occurrence of signs and symptoms of poisoning (none, salivation, disturbed ventilation and fasciculations,
more » ... nvulsions, or death) were summarised and compared. When blood enzyme activities were 70-100% normal, no obvious signs were seen; at 60-70%, salivation Military Medical Academy, 502 60 Hradec Krilov6, Czechoslovakia J Bajgar 648 c,.
doi:10.1136/oem.49.9.648 fatcat:gi7csjzd6bgf5gluegiold2vay