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Intrinsic signals regulate the initial steps of myogenesis in vertebrates
2003
Development
Preserved Fulltext
presomitic mesoderm, represents the MyoD-activating cue. Despite Wnt5b expression in the presomitic mesoderm, MyoD is not expressed in this tissue: our experiments demonstrate that this is due to a Bmp inhibitory signal that prevents the premature expression of MyoD before somites form. Our results indicate that myogenesis is a multistep process which is initiated prior to somite formation in a mesoderm-autonomous fashion; as somites form, influences from adjacent tissues are likely to be
doi:10.1242/dev.00688
pmid:12917295
fatcat:weo5fnz4mnhmzpbsedwsi4ni7m