Intrinsic signals regulate the initial steps of myogenesis in vertebrates

C. Linker
2003 Development  
presomitic mesoderm, represents the MyoD-activating cue. Despite Wnt5b expression in the presomitic mesoderm, MyoD is not expressed in this tissue: our experiments demonstrate that this is due to a Bmp inhibitory signal that prevents the premature expression of MyoD before somites form. Our results indicate that myogenesis is a multistep process which is initiated prior to somite formation in a mesoderm-autonomous fashion; as somites form, influences from adjacent tissues are likely to be
more » ... ed for maintenance and patterning of early muscles.
doi:10.1242/dev.00688 pmid:12917295 fatcat:weo5fnz4mnhmzpbsedwsi4ni7m