Fetal hemoglobin that binds oxygen more strongly than adult hemoglobin saves children (and sickle-cell patients where it persists longer) from heme-binding (oxygen sequestering) proteins of anaerobic bacteria (Prevotella, et al) - thereby making SARS-Cov2 benign for them [post]

Sandeep Chakraborty
2020 unpublished
Here, I postulate (supported by sequencing data from patients) rationale behind two of the most critical (low SpO2 [1], need for ventilators) and baffling (doesnt effect children or malaria endemic regions [2]) effects observed in SARS-Cov2 [3–6]. In short, secondary infection with anaerobic bacteria [7–9] which express heme-expressing proteins, and can degrade and utilize hemoglobin as an effective heme source [10, 11] - causing oxygen levels (which binds to heme) to go down. Also, Prevotella
more » ... . Also, Prevotella is known to lower lymphocyte counts [12], increase IL-6 in plasma [13–15], cause ground glass opacity in lungs [16], and associated with cardiac injury [17] - all symptoms associated with Covid19.
doi:10.31219/osf.io/vzmf3 fatcat:rnlujrudgfdujmigy4m75xqodq