Cystatin C and Its Role in Patients with Type 1 and Type 2 Diabetes Mellitus

Alaaeldin M. Bashier, Ayman Aly Seddik Fadlallah, Nada Alhashemi, Puja Murli Thadani, Elamin Abdelgadir, Fauzia Rashid
2015 Advances in Endocrinology  
Diabetes mellitus is the commonest cause of CKD. It is the leading cause of new patients requiring renal replacement therapy, accounting for 40%, 34%, and 30% of cases in United States, Germany, and Australia, respectively. Recent studies have shown that a low-molecular weight protein, cystatin C, freely filtered by the kidneys is a novel biomarker that may be used for detection of early renal dysfunction in patients with type 1 or type 2 diabetes. Cystatin C has also been shown to detect
more » ... own to detect cardiovascular disease in patients with diabetes and it may also be linked with incident type 2 diabetes in obese patients. We aim to review current evidence based literature on use of cystatin C for early detection of diabetic nephropathy due to type 1 and type 2 diabetes in comparison to conventional methods and explore its association with other comorbidities.
doi:10.1155/2015/254042 fatcat:eprh3kxqxndmdb7zhoooncval4