Organizing a tête-à-tête between cell adhesion molecules and extracellular proteases: a risky business that could lead to the survival of tumor cells

Yves, St-Pierre
2005 Frontiers in Bioscience  
TABLE OF CONTENTS 1. Abstract 2. The role of cell adhesion molecules in cancer progression 2.1. Recruitment of effector cells 2.2. The role of ICAM-1 in the dissemination of tumor cells 2.3. The role of selectins in cancer progression 3. Soluble forms of adhesion molecules during cancer 3.1. The presence of circulating forms of adhesion molecules 3.2. Sensitivity of LFA-1-ICAM-1 interactions to proteolytic cleavage 3.3. Alternative splicing regulates the cleavage of adhesion molecules 3.4. The
more » ... molecules 3.4. The cleavage of adhesion molecules by proteases of different sources 4. Implications of the proteolytic cleavage of adhesion molecules during anti-tumoral immune response 4.1. Modulating the recruitment of effector cells 4.2. Escaping immune surveillance through the absence of co-stimulatory signals 5. Conclusions 6. Acknowledgement 7. References
doi:10.2741/1597 pmid:15769603 fatcat:i2ghwntaz5ho3afo7kfc5h2lfu