Anti-Inflammatory, and Anti-Nociceptive Properties of Leaf and Root Extracts of Amaranthus spinosus

Hashim Mushtasin Reza, MN Islam
2020 Figshare  
Inflammation is the body's protective retaliation to obnoxious stimuli, damage and infection. Despite eliciting repairing function, inflammation over prolonged periods of time can lead to the development of severe conditions such as cancer, and numerous cardiovascular, metabolic, neurological, and renal disorders. In this experiment, the ethanolic extracts of Amaranthus spinosus L. leaves and roots were evaluated for anti-inflammatory and antinociceptive potential using the acetic acid induced
more » ... cetic acid induced writhing, tail immersion, and hot plate test with mice. Results showed that the extracts of both leaves and roots had reduced inflammation and nociceptive pain. The 500 mg/kg doses of both plant parts showed the most significant results. Both plant part extracts were observed to elicit pain relief effects comparable to a diclofenac sodium, and morphine. The mechanism of this effect may be through the non-selective inhibition of cyclooxygenase-2 (COX-2) enzyme, and activation of µ opioid receptor. The 500mg/kg root extract showed highest antiinflammatory and antinociceptive action.
doi:10.6084/m9.figshare.12295814 fatcat:ygph2qwcwjecxbf6uodieo55r4