Relationship Between HbA1c and Serum Magnesium Levels in Patients with Type 2 Diabetes Mellitus

Senan Arslan, Halil İbrahim Erdoğdu, Eray Atalay
2021 Kafkas Journal of Medical Sciences  
Aim: The study aimed to investigate the relationship between serum magnesium levels and serum glucose regulation in type 2 diabetes mellitus (T2DM) patients. Material and Method: 152 subjects with known T2DM and 57 individuals with no known T2DM history who were applicants to the Internal Medicine Polyclinic of the Kafkas University Medical Faculty Hospital were included in the study. The patient group was classified as having <6.5% or ≥6.5% HbA1 c levels and <1.6 or ≥1.6 (mg/dl) Mg levels.
more » ... /dl) Mg levels. Results: A significant negative correlation was detected between Mg levels and HbA1 c levels (r=-0.391, r 2 =0.153, p<0.001). Similarly; Mg, HbA1 c, HDL, Triglyceride, Total Cholesterol, Fasting Insulin, Fasting Glucose, HOMA-IR levels were significantly different in patients compared to the control group (p<0.05). In addition, no significant difference was found between the levels of Vitamin D, HDL, LDL, Triglyceride, Total Cholesterol, Calcium, Phosphorus and Fasting insulin in the analysis of the groups in which the patients were divided into HbA1 c <6.5% and HbA1 c ≥6.5%. (P>0.05). The difference was statistically significant when comparing Mg (<0.001), HOMA-IR (0.039) and fasting glucose levels (<0.001) among these groups. Conclusion: Serum Mg levels in T2DM patients were lower than in healthy control subjects. Also, lower Mg levels were found in T2DM patients in whom blood glucose regulation was not achieved. These findings demonstrate the importance of monitoring magnesium levels and working on treatment strategies in diabetic patients in order to overcome the vicious cycle between T2DM and Mg deficiency.
doi:10.5505/kjms.2021.68878 fatcat:sy6jhdma2rgafbiz4s6nxi3pbm